CRISPR-Cas: Adapting to change
نویسندگان
چکیده
منابع مشابه
The CRISPR/Cas System
The epigenome is a heritable layer of information not encoded in the DNA sequence of the genome, but in chemical modifications of DNA or histones. These chemical modifications, together with transcription factors, operate as spatiotemporal regulators of genome activity. Dissecting epigenome function requires controlled site-specific alteration of epigenetic information. Such control can be obta...
متن کاملSpecial focus CRISPR-Cas
Six years ago a new sophisticated prokaryotic defense system was identified that was termed CRISPR-Cas (CRISPR, clustered regularly interspaced short palindromic repeats; Cas, CRISPR associated). Parts of it, the mysterious repeat sequences, were already detected in 1987 but their function remained unknown for the next 20 y. The CRISPR-Cas system is an adaptive, heritable defense system that pr...
متن کاملCRISPR-Cas: the effective immune systems in the prokaryotes
Approximately all sequenced archaeal and half of eubacterial genomes have some sort of adaptive immune system, which enables them to target and cleave invading foreign genetic elements by an RNAi-like pathway. CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR-associated proteins) systems consist of the CRISPR loci with multiple copies of a short repeat sequence separa...
متن کاملAdapting to Change
Biologists typically use the climatic conditions in which species currently live to project the likelihood that those climates will be available following a period of climate change, and these almost always predict dramatically high rates of species extinctions and biodiversity loss in future climates. In many instances, such predictions are warranted. Polar bears (Ursus maritimus), for example...
متن کاملCRISPR-Cas: Revolutionising genome engineering.
The ability to permanently alter or repair the human genome has been the subject of a number of science fiction films, but with the recent advent of several customisable sequence-specific endonuclease technologies, genome engineering looks set to become a clinical reality in the near future. This article discusses recent advancements in the technology called 'clustered regularly interspaced pal...
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ژورنال
عنوان ژورنال: Science
سال: 2017
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aal5056